COVID19 Emerging Treatments
- Chloroquine[1]
- Antimalarial and autoimmune medicine
- Commonly found as an oral tablet
- Antiviral properties and immunomodulating effects
- Currently in FDA phase 3 study [2]
- 400mg by mouth, daily for 5 days
- One study appears to advocate a 1gm loading dose followed by 500mg BiD[3]
- There are questions on duration of treatment with this regime
- Remdesivir study[4]
- Developed by Gilead Sciences
- Investigational broad-spectrum antiviral treatment previously trialed against Ebola
- Shows good efficacy against MERS and SARS in animal studies[5]
- 200mg IV on day one then 100mg daily for a total of 10 days [6]
- University of Nebraska Medical Center study
- Oseltamivir
- Influenza A and B treatment
- Currently under investigation
- 75mg by mouth, twice per day for 5 days
- Ribavirin
- Hepatitis C antiviral treatment
- 1200mg twice per day
- Lopinavir/Ritonavir
- HIV antiviral treatment
- 400mg/100mg by mouth twice per day
- Brand name Kaletra
Vaccine Development
- Multiple laboratories are working on vaccines
- Promising trials from Hong Kong [7]
- Moderna Theraputics from Massachusetts[8]
Novavax announced on 2/26/20 it has started testing COVID-19 vaccine candidates in animal models in the hopes of identifying a candidate to be used in human testing as early as this spring[9]
[1] https://www.nature.com/articles/s41422-020-0282-0
[2] https://clinicaltrials.gov/ct2/show/NCT04261517
[3] https://www.sciencedirect.com/science/article/pii/S0924857920300820
[4] https://www.nih.gov/news-events/news-releases/nih-clinical-trial-remdesivir-treat-covid-19-begins
[5] https://www.niaid.nih.gov/news-events/remdesivir-prevents-mers-coronavirus-disease-monkeys
[6] https://www.pulmonologyadvisor.com/home/topics/lung-infection/clinical-trials-underway-to-test-remdesivir-for-covid-19/
[7] https://www.sciencedaily.com/releases/2020/02/200226091227.htm
[8] https://time.com/5790545/first-covid-19-vaccine/
[9] http://ir.novavax.com/news-releases/news-release-details/novavax-advances-development-novel-covid-19-vaccine